Impaired final follicular maturation in heifers after superovulation with recombinant human FSH

Inductions of superovulation using several FSH regimens in Holstein-Friesian heifers.

Note Eighty-three Holstein-Friesian virgin heifers were randomly divided into four groups and superovulated with one of the four FSH regimens as follows : Group I) twice daily injections of a constant dose of 5 mg of FSH for a period of 4 days, giving a total dose of 40 mg in 8 fractions ; Group II) as in Group I with additional 5 mg of FSH on the 5th day, giving a total dose of 45 mg ; Group I...

Endocrine profile in serum and follicular fluid differs after ovarian stimulation with HP-hMG or recombinant FSH in IVF patients.

BACKGROUND Highly purified menotrophin (HP-hMG) has been associated with fewer oocytes retrieved and a higher proportion of top-quality embryos compared with recombinant FSH (rFSH). METHODS A randomized, assessor-blind, multinational trial in 731 women undergoing IVF after stimulation with HP-hMG (MENOPUR) (n = 363) or rFSH (GONAL-F) (n = 368) following a long GnRH agonist protocol was conduc...

Comparing three superovulation protocols in dromedary camels: FSH, eCG-FSH and hMG

The objective of this study was to compare three superovulation protocols in dromedary camels. Follicular waves of dromedary camel donors (n=6) were synchronized using two GnRH injections. Superovulation was initiated 2 days after the second injection (day 0 of experiment). The experiment was conducted using change over design, where all females received three superovulation treatments one afte...

Characterization of the human cumulus cell transcriptome during final follicular maturation and ovulation.

Cumulus expansion and oocyte maturation are central processes in ovulation. Knowledge gained from rodent and other mammalian models has revealed some of the molecular pathways associated with these processes. However, the equivalent pathways in humans have not been thoroughly studied and remain unidentified. Compact cumulus cells (CCs) from germinal vesicle cumulus oocyte complexes (COCs) were ...

Human Menopausal Gonadotropin versus Recombinant FSH in Polycystic Ovary Syndrome Patients Undergoing In Vitro Fertilization